Thalidomide-C2-amido-C2-COOH

Names

[ Name ]:
Thalidomide-C2-amido-C2-COOH

Biological Activity

[Description]:

Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₀N₄O₇

[ Molecular Weight ]:
416.38

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-C2-amido-C2-COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds