2-Chloro-6,7-dimethoxyquinazolin-4-amine

Names

[ Name ]:
2-Chloro-6,7-dimethoxyquinazolin-4-amine

[Synonym ]:
2-chloro-6,7-dimethoxy-4-aminoquinazoline
2-chloro-6,7-dimethoxyquinazolin-4-amine
EINECS 245-821-7
2-Chloro-4-amino-6,7-dimethoxyquinazoline
2-chlor-6,7-dimethoxychinazolin-4-amin
2-Chloro-4-AMino-6
7-DiMethoxy-Quinazoline
MFCD00051734
QUINAZOLINAMINE
4-Amino-2-Chloro-6,7-Dimethoxyquinoline
4-Amino-2-chloro-6,7-dimethoxyquinazoline
2-chloro-6,7-dimethoxy-4-quinazolinylamine
2-Chloro-6,7-dimethoxy-4-quinazolinamine
4-Quinazolinamine, 2-chloro-6,7-dimethoxy-
2-Chloro-4-amino-6,7-dimethoxy
2-Chloro-4-amino-6,7-dimetoxysynazaline
4-Amino-2-chloro-6,7-dimethoxy
2-Chloro-6,7-dimethoxy-4-quinazolinamine,4-Amino-2-chloro-6,7-dimethoxyquinazoline
2-chloro-4-amino-6,7-dimethoxy quinazoline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
374.0±42.0 °C at 760 mmHg

[ Melting Point ]:
262-268 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₀ClN₃O₂

[ Molecular Weight ]:
239.658

[ Flash Point ]:
180.0±27.9 °C

[ Exact Mass ]:
239.046158

[ PSA ]:
70.26000

[ LogP ]:
1.54

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.

J. Med. Chem. 39 , 4602, (1996)

The enantiomers of [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]-fu ran- 2-ylmethanone (cyclazosin, 1) were synthesized from the chiral furan-2-yl(cis-octahydroquinoxalin-1-...

2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.

J. Med. Chem. 30(10) , 1794-8, (1987)

A series of 4-amino-6,7-dimethoxy-2(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for alpha-adrenoceptor affinity and antihypertensive activity. These quinazoline derivatives...

2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.

J. Med. Chem. 30(6) , 999-1003, (1987)

A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for alpha-adrenoceptor affinity and antihypertensive activity. These compounds displayed high...