Senexin C
Names
[ CAS No. ]:
2375554-02-0
[ Name ]:
Senexin C
Biological Activity
[Description]:
Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability.
[References]
1. Li Zhang, et al. J. Med. Chem. 2022
Chemical & Physical Properties
[ Molecular Formula ]:
C28H27N5O
[ Molecular Weight ]:
449.558