[Des-Arg9]-Bradykinin acetate

[Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

Research Areas >> Inflammation/Immunology

Peptides

Bradykinin B1 receptor[1]

[Des-Arg9]-Bradykinin acetate is a Bradykinin(B1) receptor agonist. The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively[1].

[1]. Leeb-Lundberg LM, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77.

HOE 140 TFA | Bradykinin | SSR240612 | ELN-441958 | (Des-Arg9)-Bradykinin acetate salt | Bradykinin (1-3) sulfate salt | Bradykinin Fragment 1-5 | Bradykinin (1-6) acetate salt | Bradykinin Fragment 1-7 | Bradykinin Fragment 2-9 | FR167344 free base