7-chloro-4-hydrazinoquinoline

Names

[ Name ]:
7-chloro-4-hydrazinoquinoline

[Synonym ]:
7-Chloro-4-hydrazinoquinoline
7-chloro-4-hydrazinylquinoline
QUINOLINE,7-CHLORO-4-HYDRAZINO
4-amino-7-chloroquinoline
4-Hydrazino-7-chloroquinoline
7-chloro-4-quinolylhydrazine
MFCD00006776

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
413.5ºC at 760mmHg

[ Melting Point ]:
219-225 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₈ClN₃

[ Molecular Weight ]:
193.63300

[ Flash Point ]:
203.8ºC

[ Exact Mass ]:
193.04100

[ PSA ]:
50.94000

[ LogP ]:
2.94710

[ Vapour Pressure ]:
4.8E-07mmHg at 25°C

[ Index of Refraction ]:
1.758

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB2900000

CHEMICAL NAME :: Quinoline, 7-chloro-4-hydrazino-

CAS REGISTRY NUMBER :: 23834-14-2

BEILSTEIN REFERENCE NO. :: 0141468

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H8-Cl-N3

MOLECULAR WEIGHT :: 193.65

WISWESSER LINE NOTATION :: T66 BNJ EMZ IG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,801,1969

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VB2900000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis, magnetic, spectral, and antimicrobial studies of Cu(II), Ni(II) Co(II), Fe(III), and UO2(II) complexes of a new Schiff base hydrazone derived from 7-chloro-4-hydrazinoquinoline.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 66(1) , 28-36, (2007)

A new hydrazone ligand, HL, was prepared by the reaction of 7-chloro-4-hydrazinoquinoline with o-hydroxybenzaldehyde. The ligand behaves as monoprotic bidentate. This was accounted for as the ligand c...

Synthesis and antitubercular activity of heteroaromatic isonicotinoyl and 7-chloro-4-quinolinyl hydrazone derivatives.

ScientificWorldJournal 10 , 1347-55, (2010)

Two series of N'-(E)-heteroaromatic-isonicotinohydrazide derivatives (3a-f and 4a-b) and 1-(7-chloroquinolin-4-yl)-2-[(heteroaromatic)methylene]hydrazone derivatives (5a-f and 6a-b) have been synthesi...