1,3-Dicyclohexylurea

Names

[ Name ]:
1,3-Dicyclohexylurea

[Synonym ]:
F0902-7614
MFCD00003829
Methanol, 1-(cyclohexylamino)-1-(cyclohexylimino)-, (E)-
EINECS 219-213-7
N,N'-Dicyclohexylurea
1,3-Dicyclohexylurea
N,N-Dicyclohexylurea
Urea, N,N'-dicyclohexyl-
Urea,3-dicyclohexyl
dicyclohexyl urea
N,N‘-Dicyclohexylurea
1,3-dicyclohexyl-urea
N,N'-Dicyclohexylcarbamimidic acid
DCW
N,N′-Dicyclohexylurea
Urea,N'-dicyclohexyl
1,3-dicyclohexylcarbodiimide
Urea,N,N'-dicyclohexyl

Biological Activity

[Description]:

1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vivo]

1,3-Dicyclohexylurea (Sprague Dawley rats, 30 mg/kg, Orally, once) shows antihypertensive efficacy when milled to reduce particle size, thus improving dissolution and oral bioavailability[1].

[References]

[1]. Ghosh S, et al. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. Basic Clin Pharmacol Toxicol. 2008 May;102(5):453-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
364.3±25.0 °C at 760 mmHg

[ Melting Point ]:
232-233 °C(lit.)

[ Molecular Formula ]:
C₁₃H₂₄N₂O

[ Molecular Weight ]:
224.34

[ Flash Point ]:
174.1±23.2 °C

[ Exact Mass ]:
224.188858

[ PSA ]:
41.13000

[ LogP ]:
3.85

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.586

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;N: Dangerous for the environment;

[ Risk Phrases ]:
22-51/53

[ Safety Phrases ]:
S61

[ RIDADR ]:
UN 3077 9 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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