β-Muricholic Acid

β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD)[1][2].

Research Areas >> Metabolic Disease

β-Muricholic acid (100µM; 48 h) 抑制小鼠原代肝细胞中的脂质积累[1]。

β-Muricholic acid (用 0.5% β-鼠胆酸喂食 8 周) 可预防小鼠的饮食诱导或实验性胆固醇胆结石[2]。 Animal Model: 6-8 weeks, Male C57L/J mice (with a lithogenic diet (2% cholesterol and 0.5% cholic acid))[2] Dosage: 0.5% β-muricholic acid Administration: Fed chow with 0.5% β-muricholic acid for 8 weeks Result: Decreased gallstone prevalence to 20% through significantly reducing biliary secretion rate, saturation index, and intestinal absorption of cholesterol, as well as inducing phase boundary shift and an enlarged Region E that prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.

[1]. Takada S, et al. Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. Lab Invest. 2021 Feb;101(2):193-203.  

[2]. Wang DQ, et al. Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J Lipid Res. 2002 Nov;43(11):1960-8.