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2-(6-Methoxynaphthalen-2-yl)acetic acid

Names

[ CAS No. ]:
23981-47-7

[ Name ]:
2-(6-Methoxynaphthalen-2-yl)acetic acid

[Synonym ]:
(6-Methoxy-2-naphthyl)acetic acid
(6-methoxynaphthalen-2-yl)acetic acid
2-Naphthaleneacetic acid, 6-methoxy-
6-Methoxy-2-naphthaleneacetic Acid
2-(6-methoxynaphthalen-2-yl)acetic acid

Biological Activity

[Description]:

α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
408.8±20.0 °C at 760 mmHg

[ Melting Point ]:
171-173ºC

[ Molecular Formula ]:
C13H12O3

[ Molecular Weight ]:
216.233

[ Flash Point ]:
160.7±15.3 °C

[ Exact Mass ]:
216.078644

[ PSA ]:
46.53000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.625

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ1045000
CHEMICAL NAME :
2-Naphthaleneacetic acid, 6-methoxy-
CAS REGISTRY NUMBER :
23981-47-7
BEILSTEIN REFERENCE NO. :
2371586
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H12-O3
MOLECULAR WEIGHT :
216.25
WISWESSER LINE NOTATION :
L66J CO1 H1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 119,600,1980

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2918990090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds