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Dosimertinib

Names

[ CAS No. ]:
2403760-70-1

[ Name ]:
Dosimertinib

Biological Activity

[Description]:

Dosimertinib is a highly potent, selective, and orally efficacious deuterated EGFR targeting clinical candidate for the treatment of non-small-cell lung cancer.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[References]

[1]. Meng Y, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H28D5N7O2

[ Molecular Weight ]:
504.64

Related Compounds