LP-284

Names

[ Name ]:
LP-284

Biological Activity

[Description]:

LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

[References]

[1]. Zhou J, et al. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S396.

[2]. Zhou J, et al. The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers. Blood, 2021, 138: 3991.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₀N₂O₄

[ Molecular Weight ]:
304.34

LP-284

Names

Biological Activity

Chemical & Physical Properties

Related Compounds