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IHCH-3064

Names

[ CAS No. ]:
2420562-65-6

[ Name ]:
IHCH-3064

Biological Activity

[Description]:

IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Wenzhong Yan, et al. Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A 2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents. J Med Chem. 2021 Nov 25;64(22):16573-16597.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H21N9O2

[ Molecular Weight ]:
479.49

Related Compounds