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Ivonescimab

Names

[ CAS No. ]:
2428381-53-5

[ Name ]:
Ivonescimab

Biological Activity

[Description]:

Ivonescimab (AK112) is a PD-1/VEGF Bispecific Antibody. Ivonescimab can be used for cancer research[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[In Vitro]

Ivonescimab 可与 PD-1 和 VEGFA 结合，EC50 分别为 0.06 和 0.036 nM[2]。 Ivonescimab 可与 VEGF 形成可溶性复合物 (通过 SEC-HPLC 检测)[2]。

[References]

[1]. Coward J, et al. Efficacy and safety of AK112, an anti-PD-1/VEGF-A bispecific antibody, in patients with platinum-resistant/refractory epithelial ovarian cancer in a Phase 1 study. Journal for Immuno Therapy of Cancer 2021;9:

[2]. Zhong T, et al. AK112, a tetravalent bispecific antibody targeting PD-1 and VEGF, enhances binding avidity and functional activities and elicits potent anti-tumor efficacy in pre-clinical studies. Journal for Immuno Therapy of Cancer. 2022;10:

[3]. Qu T, et al. Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity. Journal for Immuno Therapy of Cancer. 2022;10:e005517.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds