cis-5-dodecenoic acid

Names

[ Name ]:
cis-5-dodecenoic acid

[Synonym ]:
dodec-5c-enoic acid
5-Dodecenoic acid
CIS-5-DECENOICACID
cis-dodec-5-enoic acid
Dodec-5c-ensaeure
CIS-5-DODECENOIC ACID
MFCD00239341

Biological Activity

[Description]:

cis-5-Dodecenoic acid is an endogenous metabolite with inhibitory activities against COX-I and COX-II[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

Human Endogenous Metabolite

COX-1

COX-2

[References]

[1]. Henry GE, et al. Antioxidant and cyclooxygenase activities of fatty acids found in food. J Agric Food Chem. 2002 Apr 10;50(8):2231-4.

Chemical & Physical Properties

[ Density]:
0.922g/cm3

[ Boiling Point ]:
310.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₂₂O₂

[ Molecular Weight ]:
198.30200

[ Flash Point ]:
207.7ºC

[ Exact Mass ]:
198.16200

[ PSA ]:
37.30000

[ LogP ]:
3.76790

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.454(lit.)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
34

[ Safety Phrases ]:
23-26-27-36/37/39-45

[ RIDADR ]:
UN 3265 8/PG 2

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Decenoic, dodecenoic, and tetradecenoic acids in the Lactobacteriaceae.

Biochemistry 4(8) , 1621-7, (1965)

Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB.

J. Biol. Chem. 284(43) , 29526-35, (2009)

Although the unsaturated fatty acid (UFA) synthetic pathway of Escherichia coli is the prototype of such pathways, several unresolved issues have accumulated over the years. The key players are the fa...

Oxidation of cis-5-unsaturated fatty acids in intact rat liver mitochondria: the operation of reduction pathways.

Biochem. J. 308 ( Pt 1) , 39-44, (1995)

The metabolism of cis-5 unsaturated fatty acids was studied in intact rat liver mitochondria to assess the operation of a reduction pathway. By using direct quantification of metabolites with a capill...