Iperoxo

Names

[ Name ]:
Iperoxo

[Synonym ]:
4-(4,5-Dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethyl-2-butyn-1-aminium iodide
2-Butyn-1-aminium, 4-[(4,5-dihydro-3-isoxazolyl)oxy]-N,N,N-trimethyl-, iodide (1:1)
MFCD26793886

Biological Activity

[Description]:

An extremely potent muscarinic receptor agonist with EC50 of 2.12 nM and 8.47 nM for M2 and M4, respectively; significantly exceeds ACh in Gi /Gs signalling competence CHO-hM2 cells.

[References]

References 1. Schrage R, et al. Br J Pharmacol. 2013 May;169(2):357-70. 2. Kruse AC, et al. Nature. 2013 Dec 5;504(7478):101-6. 3. Croy CH, et al. Mol Pharmacol. 2014 Jul;86(1):106-15. View Related Products by Target mAChR

Chemical & Physical Properties

[ Melting Point ]:
211.5 - 212.5 °C

[ Molecular Formula ]:
C₁₀H₁₇IN₂O₂

[ Molecular Weight ]:
324.159

[ Exact Mass ]:
324.033478

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ RIDADR ]:
NONH for all modes of transport

Articles

Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.

Eur. J. Med. Chem. 75 , 222-32, (2014)

In this study, we synthesized and tested in vitro and in vivo two groups of bis(ammonio)alkane-type compounds, 6a-9a and 6b-9b, which incorporate the orthosteric muscarinic agonist iperoxo into a mole...