Ethyl 4-hydroxyquinoline-2-carboxylate

Names

[ Name ]:
Ethyl 4-hydroxyquinoline-2-carboxylate

[Synonym ]:
2-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester
Ethyl 4-oxo-1,4-dihydro-2-quinolinecarboxylate
Ethyl 4-hydroxyquinoline-2-carboxylate
ETHYL 4-HYDROXY-2-QUINOLINECARBOXYLATE
Kynurenic acid ethyl ester
MFCD01863732

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
343.7±42.0 °C at 760 mmHg

[ Melting Point ]:
216-218ºC(lit.)

[ Molecular Formula ]:
C₁₂H₁₁NO₃

[ Molecular Weight ]:
217.221

[ Flash Point ]:
161.7±27.9 °C

[ Exact Mass ]:
217.073898

[ PSA ]:
59.42000

[ LogP ]:
2.57

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.569

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Br. J. Pharmacol. 162 , 733-748, (2011)

GPR35 is a poorly characterized G protein-coupled receptor at which kynurenic acid has been suggested to be the endogenous ligand. We wished to test this and develop assays appropriate for the study o...