NR-160
Names
[ CAS No. ]:
2484895-50-1
[ Name ]:
NR-160
Biological Activity
[Description]:
NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.NR-160 induced α-tubulin acetylation (ac-α-tubulin) in treated acute myeloid leukemic (AML) cell line HL60, but not histone H3 (ac-H3) (a marker for the inhibition of class I HDACs).NR-160 enhances the cytotoxicity induction of bortezomib, epirubicin and daunorubicin on a panel of seven leukemia cell lines
[References]
1. Nina Reßing, et al. J Med Chem. 2020 Sep 24;63(18):10339-10351.
Chemical & Physical Properties
[ Molecular Formula ]:
C25H21F3N6O3
[ Molecular Weight ]:
510.477