SIRT6 activator CL5D

Names

[ Name ]:
SIRT6 activator CL5D

Biological Activity

[Description]:

SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.CL5D demonstrate competitive inhibition with Ki of 13.4 uM.CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells.

[References]

1. Mark A Klein, et al. J Biol Chem. 2020 Jan 31;295(5):1385-1399.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₁₁Cl₇N₂O₆

[ Molecular Weight ]:
731.565

Related Compounds

SIRT6 activator 12q
SIRT6-IN-1
SIRT6-IN-5
Bax activator compound 106
TRPV1 activator-1
Nrf2 activator-1
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
3-Iodo-2-(2,2,2-trifluoroacetamido)-5-(trifluoromethyl)benzoic acid
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide