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Beloranib

Names

[ CAS No. ]:
251111-30-5

[ Name ]:
Beloranib

[Synonym ]:
[(3R,6R,7S,8S)-7-methoxy-8-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] (E)-3-[4-(2-dimethylaminoethyloxy)phenyl]prop-2-enoate
(3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-yl (2E)-3-(4-(2-(dimethylamino)ethoxy)phenyl)prop-2-enoate
Beloranib
UNII-FI471K8BU6
O-(4-(2-Dimethylaminoethoxy)-trans-cinnamoyl)fumagillol
Beloranib [INN]
ZGN-433

Biological Activity

[Description]:

Beloranib is an antiangiogenic fumagillin derivative. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.

[References]

[1]. Elfers CT, Roth CL. Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity. Endocrinology. 2017;158(1):41-55.

[2]. Kim YM, An JJ, Jin YJ, et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol. 2007;38(4):455-465.

[3]. Lee HS, Choi WK, Son HJ, et al. Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs. Arch Pharm Res. 2004;27(2):265-272.

[4]. Kim EJ, Shin WH. General pharmacology of CKD-732, a new anticancer agent: effects on central nervous, cardiovascular, and respiratory system. Biol Pharm Bull. 2005;28(2):217-223.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₁NO₆

[ Molecular Weight ]:
499.63900

[ Exact Mass ]:
499.29300

[ PSA ]:
73.06000

[ LogP ]:
4.25980

[ Storage condition ]:
-20°C

Related Compounds