17beta(h),21beta(h)-hop-22(29)-en-3-one

3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory[1].

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

3-Oxo-hop-22(29)-ene (compound 2) (50 μM; 24 hours) reduces the viability of T. cruzi by more than 20%, and has a moderate effecton on T. rangeli and L. mexicana[1]. 3-Oxo-hop-22(29)-ene (10, 100 μM; 48 hours) causes 1.51% and 7.39% inhibition activity to yeast α-glucosidase respectively[1]. Cell Viability Assay[1] Cell Line: Saccharomyces cerevisiae (type 1) and mammalian yeast (type 2) α-glucosidases, T. cruzi, T. rangeli, L. mexicana Concentration: 10 μM, 50 μM, 100 μM Incubation Time: 24 hours, 48 hours Result: Reduced the viability of T. cruzi by more than 20%, and had a moderate effecton on T. rangeli and L. mexicana Inhibited Yeast α-glucosidase.

3-Oxo-hop-22(29)-ene (0.31 μmol/ear; application; once) decreases 17.50 % the inflammation of mouse ear edema model[1]. Animal Model: Adult male CD-1 mice (25-30 g) (Mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA))[1] Dosage: 0.31 μmol/ear Administration: Apply to both faces of the right ear; once Result: Decreased 17.50% the inflammation of mouse ear edema model.

[1]. López-Huerta FA, et al. Hopane-type triterpenes from Cnidoscolus spinosus and their bioactivities. Bioorg Chem. 2020 Jul;100:103919.