Acetamide,2-chloro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Names
[ CAS No. ]:
26279-89-0
[ Name ]:
Acetamide,2-chloro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
[Synonym ]:
17-Chlorocolchicine
COLCHICINE,17-CHLORO
Chlorcolchicine
Chlorocolchicine
Chemical & Physical Properties
[ Density]:
1.31g/cm3
[ Boiling Point ]:
746.3ºC at 760mmHg
[ Molecular Formula ]:
C22H24ClNO6
[ Molecular Weight ]:
433.88200
[ Flash Point ]:
405.1ºC
[ Exact Mass ]:
433.12900
[ PSA ]:
83.09000
[ LogP ]:
3.48140
[ Vapour Pressure ]:
3.8E-22mmHg at 25°C
[ Index of Refraction ]:
1.591
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0740000
- CHEMICAL NAME :
- Colchicine, 17-chloro-
- CAS REGISTRY NUMBER :
- 26279-89-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C22-H24-Cl-N-O6
- MOLECULAR WEIGHT :
- 433.92
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMV1G NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1251 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981