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AG 045572

Names

[ CAS No. ]:
263847-55-8

[ Name ]:
AG 045572

[Synonym ]:
Ambenonium dichloride
Furan-1
CMPD-1

Biological Activity

[Description]:

AG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor
Research Areas >> Endocrinology

[References]

[1]. Iatsimirskaia EA, et al. Effect of testosterone suppression on the pharmacokinetics of a potent gnRH receptor antagonist. Pharm Res. 2002 Feb;19(2):202-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H37NO5

[ Molecular Weight ]:
491.62

[ Exact Mass ]:
491.26700

[ PSA ]:
69.93000

[ LogP ]:
6.87890

Related Compounds