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RORγt/DHODH-IN-2

Names

[ CAS No. ]:
2641758-86-1

[ Name ]:
RORγt/DHODH-IN-2

Biological Activity

[Description]:

RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR
Research Areas >> Inflammation/Immunology

[References]

[1]. Ji-An Chen, et al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H30N4OS

[ Molecular Weight ]:
434.60

Related Compounds