ritodrine

Names

[ Name ]:
ritodrine

[Synonym ]:
ritodrine
Yutopar S.R
Ritodrina
Utopar
Ritodrinium
Yutopar
Prepar

Biological Activity

[Description]:

Ritodrine (DU21220) is a β-adrenergic agonist, also an effective uterine relaxant, can be used for researching arrest premature labor[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[References]

[1]. Spellacy WN, et al. Treatment of premature labor with ritodrine: a randomized controlled study. Obstet Gynecol. 1979 Aug;54(2):220-3.

[2]. Canadian Preterm Labor Investigators Group. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med. 1992 Jul 30;327(5):308-12.

Chemical & Physical Properties

[ Density]:
1.213g/cm3

[ Boiling Point ]:
512.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₁NO₃

[ Molecular Weight ]:
287.35400

[ Flash Point ]:
175.6ºC

[ Exact Mass ]:
287.15200

[ PSA ]:
72.72000

[ LogP ]:
2.74290

[ Vapour Pressure ]:
2.55E-11mmHg at 25°C

[ Index of Refraction ]:
1.618

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA4797050

CHEMICAL NAME :: Benzenemethanol, 4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)e thyl)-, (R*,S*)-

CAS REGISTRY NUMBER :: 26652-09-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H21-N-O3

MOLECULAR WEIGHT :: 287.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

DOSE :: 21040 ug/kg

SEX/DURATION :: female 10-35 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: EOGRAL European Journal of Obstetrics, Gynecology and Reproductive Biology. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.3- 1973- Volume(issue)/page/year: 59,137,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 3000 ug/kg

SEX/DURATION :: female 20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: BMMBES Biochemical Medicine and Metabolic Biology. (Academic Press, Inc., Journal Customer Service, POB 6250, Duluth, MN 55802-0250) V.35- 1986- Volume(issue)/page/year: 52,128,1994