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picraline

Names

[ CAS No. ]:
2671-32-1

[ Name ]:
picraline

[Synonym ]:
2H,12H-6,12a-Epoxy-2,7a-methanoindolo[2,3-a]quinolizine-14-carboxylic acid, 14-[(acetyloxy)methyl]-3-ethylidene-1,3,4,6,7,12b-hexahydro-, methyl ester, (2R,3E,6S,7aS,12aR,12bS)-
Methyl (2α,5α,15α,19E)-16-(acetoxymethyl)-1,2-dihydro-2,5-epoxyakuammilan-17-oate

Biological Activity

[Description]:

Picraline is a natural alkaloid that targets opioid receptors with binding affinities with Ki values of 132 μM, 2.38 μM and 98.8 μM for μOR, κOR and δOR, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

μ Opioid Receptor/MOR:132 μM (Ki)

κ Opioid Receptor/KOR:2.38 μM (Ki)

δ Opioid Receptor/DOR:98.8 μM (Ki)


[References]

[1]. Simone M Creed, et al. Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. J Nat Prod. 2021 Jan 22;84(1):71-80.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
548.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H26N2O5

[ Molecular Weight ]:
410.46

[ Flash Point ]:
285.2±30.1 °C

[ Exact Mass ]:
410.184174

[ PSA ]:
77.10000

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.650

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds