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Coronalolic acid

Names

[ CAS No. ]:
268214-52-4

[ Name ]:
Coronalolic acid

[Synonym ]:
Coronalolic acid
1H-Cyclopenta[a]cyclopropa[e]naphthalene-6a(7H)-propanoic acid, 1-[(1R,4E)-1,5-dimethyl-6-oxo-4-hexen-1-yl]decahydro-6-[1-(hydroxymethyl)ethenyl]-3a,9a-dimethyl-, (1R,3aS,3bS,6R,6aR,7aS,9aR)-
3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a-dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyclopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid

Biological Activity

[Description]:

Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

NF-κB


[In Vitro]

Coronalolic acid has an inhibition effect against the TNF-α-induced NF-κB activity and NO production with IC50s of 15.4 μM and 15.0 μM in LPS-stimulated RAW 264.7 cells, respectively[1].

[References]

[1]. Youn UJ, et al. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. Fitoterapia. 2016 Oct;114:92-97.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
608.7±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H46O4

[ Molecular Weight ]:
470.684

[ Flash Point ]:
335.9±19.7 °C

[ Exact Mass ]:
470.339600

[ PSA ]:
74.60000

[ LogP ]:
7.24

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.551

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds