Phenyl[(2H5)phenyl]methanone

Names

[ Name ]:
Phenyl[(2H5)phenyl]methanone

[Synonym ]:
Phenyl[(H)phenyl]methanone
2,3,4,5,6-pentadeuterio-benzophenone
benzophenone-2,3,4,5,6-d5
Methanone, phenylphenyl-d-
MFCD00084123
benzophenone-d5
2,3,4,5,6-Pentadeuteriobenzophenon

Biological Activity

[Description]:

Benzophenone-d5 is the deuterium labeled Benzophenone[1]. Benzophenone is an endogenous metabolite.

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
305.4±0.0 °C at 760 mmHg

[ Melting Point ]:
47-51ºC(lit.)

[ Molecular Formula ]:
C₁₃H₅D₅O

[ Molecular Weight ]:
187.249

[ Flash Point ]:
123.7±13.7 °C

[ Exact Mass ]:
187.104553

[ PSA ]:
17.07000

[ LogP ]:
3.18

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.584

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Photolytic fate and genotoxicity of benzophenone-derived compounds and their photodegradation mixtures in the aqueous environment.

Chemosphere 147 , 114-23, (2016)

This study investigates the environmental fate of eight benzophenone derivatives (the pharmaceutical ketoprofen, its phototransformation products 3-ethylbenzophenone and 3-acetylbenzophenone, and five...