STING agonist-31

Names

[ CAS No. ]:
2719001-44-0

[ Name ]:
STING agonist-31

Biological Activity

[Description]:

STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> STING

[In Vitro]

STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING，EC50 值为 0.24 和 39.51 μM[1]。 STING agonist-31 (0-10 μM，24 h) 激活 ISG 信号和 NF-κB 信号[1]。

[In Vivo]

STING agonist-31 (化合物 40) (10 mg/kg，静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。 STING agonist-31 (1 mg/kg，静脉注射) 在大鼠中显示出 T1/2：0.697 h，AUClast 678 h•ng/mL[1]< /sup>. Animal Model: Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] Dosage: 10 mg/kg Administration: i.v., at days 1, 4, and 7 Result: Inhibited tumor Growth.

[References]

[1]. Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669.  

Chemical & Physical Properties

[ Molecular Formula ]:
C43H51N15O6

[ Molecular Weight ]:
873.96

Related Compounds