Treprostinil-d9

Names

[ CAS No. ]:
2747918-14-3

[ Name ]:
Treprostinil-d9

Biological Activity

[Description]:

Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441)[1]. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

EC50: 0.6±0.1 nM (DP1), 6.2±1.2 nM (EP2)[1]


[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H25D9O5

[ Molecular Weight ]:
399.57

Related Compounds