Tilorone
Names
[ CAS No. ]:
27591-97-5
[ Name ]:
Tilorone
[Synonym ]:
UNII-O6W7VEW6KS
Tilorone
Amixin IC
2,7-Bis-DEAE-fluorenone
Tilorone base
Tilorone hydrochloride
2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-
Bis-DEAE-fluorenone
9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-
L B656 HVJ EO2N2&2 KO2N2&2
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
552.3±50.0 °C at 760 mmHg
[ Molecular Formula ]:
C25H34N2O3
[ Molecular Weight ]:
410.549
[ Flash Point ]:
287.8±30.1 °C
[ Exact Mass ]:
410.256958
[ PSA ]:
42.01000
[ LogP ]:
5.25
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.564
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LL8990000
- CHEMICAL NAME :
- 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-
- CAS REGISTRY NUMBER :
- 27591-97-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C25-H34-N2-O3
- MOLECULAR WEIGHT :
- 410.61
- WISWESSER LINE NOTATION :
- L B656 HVJ EO2N2&2 KO2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1780 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 121 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Immunological Including Allergic - increased immune response Tumorigenic - active as anti-cancer agent
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 11,91,1975