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SOS1-IN-8

Names

[ CAS No. ]:
2759387-92-1

[ Name ]:
SOS1-IN-8

Biological Activity

[Description]:

SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

SOS1-G12D:11.6 nM (IC50)

SOS1-G12V:40.7 nM (IC50)

[References]

[1]. Fused pyridazine derivative, preparation method therefor and pharmaceutical use thereof. WO2022017339A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₆F₃N₃O₄

[ Molecular Weight ]:
477.48

Related Compounds