mGluR5 antagonist-1

Names

[ CAS No. ]:
2761424-76-2

[ Name ]:
mGluR5 antagonist-1

Biological Activity

[Description]:

mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> mGluR

[References]

[1]. Yonglei Du, et al. Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice. Eur J Med Chem. 2023.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H18N4O2

[ Molecular Weight ]:
382.41

Related Compounds