MRL-1237

Names

[ Name ]:
MRL-1237

Biological Activity

[Description]:

MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein; inhibits poliovirus-specific RNA synthesis in HeLa cells infected with a wild strain but not with an F164Y mutant.

[References]

References 1. Shimizu H, et al. J Virol. 2000 May;74(9):4146-54. 2. De Palma AM, et al. J Virol. 2008 May;82(10):4720-30. View Related Products by Target Enterovirus

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆ClFN₄

[ Molecular Weight ]:
354.813

Related Compounds

N,N-diethyl-2-[4-[2-(4-methoxyphenyl)-1-phenylethyl]phenoxy]ethanamine,2-hydroxypropane-1,2,3-tricarboxylic acid
MRL-494
MRL-871
SDZ MRL 953
6-chloro-N-(pyridin-2-ylmethyl)pyridazin-3-amine
LY 367385
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(5-(benzo[d][1,3]dioxol-5-ylmethyl)-1,3,4-oxadiazol-2-yl)-2-(m-tolyl)acetamide
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
(5-(Furan-2-yl)isoxazol-3-yl)(3-methylmorpholino)methanone
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1-(1,3-Benzodioxol-5-yl)-4-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]-2-pyrrolidinone