IL-1β-IN-1

Names

[ CAS No. ]:
2780364-50-1

[ Name ]:
IL-1β-IN-1

Biological Activity

[Description]:

IL-1β-IN-1, cannabidiol derivative, is a potent IL-1β inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[Target]

IL-1β


[In Vivo]

IL-1β-IN-1 (compound 2; 10 and 25 mg/kg; i.p.; 雌性 Sabra 小鼠) 以剂量依赖性方式改善肿胀和痛感[1]。 Animal Model: female Sabra mice, 7-8 weeks old[1] Dosage: 10 and 25 mg/kg Administration: intraperitoneal injection Result: Reduced swelling and pain sensation. Reduced plasma TNFα and IL-1β.

[References]

[1]. Lavi Y, et, al. Novel Synthesis of C-Methylated Phytocannabinoids Bearing Anti-inflammatory Properties. J Med Chem. 2023 Apr 27;66(8):5536-5549.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H34O2

[ Molecular Weight ]:
330.50

Related Compounds