6-acetylmorphine

Names

[ Name ]:
6-acetylmorphine

[Synonym ]:
[(4R,4aR,7S,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] acetate

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
470.2ºC at 760mmHg

[ Melting Point ]:
184-189ºC

[ Molecular Formula ]:
C₁₉H₂₁NO₄

[ Molecular Weight ]:
327.37400

[ Flash Point ]:
238.2ºC

[ Exact Mass ]:
327.14700

[ PSA ]:
59.00000

[ LogP ]:
1.70680

[ Vapour Pressure ]:
1.83E-09mmHg at 25°C

[ Index of Refraction ]:
1.665

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QC7814500

CHEMICAL NAME :: Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, 6-acetate

CAS REGISTRY NUMBER :: 2784-73-8

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H21-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 85,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 85,317,1982

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312-H319-H331

[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338-P311

[ Hazard Codes ]:
F: Flammable;Xn: Harmful;

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
16-36/37-26

[ RIDADR ]:
UN 1648 3/PG 2

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Dynamic vaccine blocks relapse to compulsive intake of heroin.

Proc. Natl. Acad. Sci. U. S. A. 110(22) , 9036-41, (2013)

Heroin addiction, a chronic relapsing disorder characterized by excessive drug taking and seeking, requires constant psychotherapeutic and pharmacotherapeutic interventions to minimize the potential f...

Validation of a gas chromatography-ion trap-tandem mass spectrometry assay for the simultaneous quantification of cocaine, benzoylecgonine, cocaethylene, morphine, codeine, and 6-acetylmorphine in aqueous solution, blood, and skeletal muscle tissue.

J. Anal. Toxicol. 36(1) , 1-11, (2012)

A gas chromatography-ion trap-tandem mass spectrometry method was developed and validated for the simultaneous solid-phase extraction and quantification of cocaine, benzoylecgonine, cocaethylene, morp...

Simultaneous determination of xylazine, free morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in postmortem blood by UPLC-MS-MS.

J. Anal. Toxicol. 36(5) , 319-26, (2012)

Xylazine, a veterinary sedative, has been found as an adulterant of heroin in street drugs in Puerto Rico. It was found in combination with free morphine and 6-acetylmorphine, codeine, cocaine and ben...