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MRV03-037

Names

[ CAS No. ]:
2797066-28-3

[ Name ]:
MRV03-037

Biological Activity

[Description]:

MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

MRV03-037 (compound 1; 0.01 nM-0.1 mM for 1 h) inhibits ClbP acitivity in E. coli BL21 overexpressing ClbP[1].

[References]

[1]. Volpe MR, et al. A small molecule inhibitor prevents gut bacterial genotoxin production. Nat Chem Biol. 2022 Oct 17.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H19BN2O4

[ Molecular Weight ]:
230.07

Related Compounds