3-Methoxy-1,5,8-trihydroxyxanthone

Names

[ Name ]:
3-Methoxy-1,5,8-trihydroxyxanthone

[Synonym ]:
1,5,8-trihydroxy-3-methoxyxanthone
9H-Xanthen-9-one, 1,5,8-trihydroxy-3-methoxy-
Bellidifolin
3-Methoxy-1,5,8-trihydroxyxanthen-9-one
1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one
bellidifodin
3-Methoxy-1,5,8-trihydroxyxanthone
1,5,8-trihydroxy-3-methoxyxanthen-9-one
1,5,8-Trihydroxy-3-methoxy-xanthen-9-on
1,5,8-trihydroxy-3-methoxy-xanthen-9-one
Bellidifolium
Bellidifoline

Biological Activity

[Description]:

Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities[1][2][3]. Bellidifolin also acts as a viral protein R (Vpr) inhibitor[4].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[References]

[1]. Zhao ZY, et al. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms. J Toxicol Environ Health A. 2017;80(22):1187-1192.

[2]. Zheng XY, et al. Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo. J Ethnopharmacol. 2014 May 14;153(3):854-63.

[3]. Basnet P, et al. Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Planta Med. 1994 Dec;60(6):507-11.

[4]. Woo SY, et al. Viral protein R inhibitors from Swertia chirata of Myanmar. J Biosci Bioeng. 2019 May 7.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
580.2±50.0 °C at 760 mmHg

[ Melting Point ]:
265-267ºC

[ Molecular Formula ]:
C₁₄H₁₀O₆

[ Molecular Weight ]:
274.226

[ Flash Point ]:
228.0±23.6 °C

[ Exact Mass ]:
274.047729

[ PSA ]:
100.13000

[ LogP ]:
0.90

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.714

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZD6116500

CHEMICAL NAME :: Xanthen-9-one, 3-methoxy-1,5,8-trihydroxy-

CAS REGISTRY NUMBER :: 2798-25-6

BEILSTEIN REFERENCE NO. :: 0288441

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H10-O6

MOLECULAR WEIGHT :: 274.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%