2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid

Names

[ Name ]:
2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid

Biological Activity

[Description]:

10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vivo]

给予 1.3 mmol/kg 甲硫氨酸 30 分钟和 60 分钟后，雄性 Sprague-Dawley 大鼠肝脏中的 10-甲酰四氢叶酸显着增加[1]。

[References]

[1]. Donald W Horne, et al. Neither methionine nor nitrous oxide inactivation of methionine synthase affect the concentration of 5,10-methylenetetrahydrofolate in rat liver. J Nutr. 2003 Feb;133(2):476-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃N₇O₇

[ Molecular Weight ]:
473.43900

[ Exact Mass ]:
473.16600

[ PSA ]:
219.84000

[ LogP ]:
1.15290