SHP2-IN-22

Names

[ Name ]:
SHP2-IN-22

Biological Activity

[Description]:

SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Hou Q, et al. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers. J Med Chem. 2023 Oct 12;66(19):13646-13664.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂Cl₂N₈O

[ Molecular Weight ]:
497.38