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Ro 64-6198

Names

[ CAS No. ]:
280783-56-4

[ Name ]:
Ro 64-6198

[Synonym ]:
1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-
Ro64-6198
8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Biological Activity

[Description]:

Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued

[References]

References 1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64. 2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23. 3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43. View Related Products by Target Opioid Receptor Anxiety

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
626.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H31N3O

[ Molecular Weight ]:
401.544

[ Flash Point ]:
332.5±31.5 °C

[ Exact Mass ]:
401.246704

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.668

Related Compounds