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WD2000-012547

Names

[ CAS No. ]:
283172-68-9

[ Name ]:
WD2000-012547

[Synonym ]:
WD2000-012547

Biological Activity

[Description]:

WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.

[Related Catalog]:

Research Areas >> Cancer

[Target]

PARP-1:8.221 (pKi)


[In Vitro]

Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pKi of 8.221[1].

[References]

[1]. Fatima S, et al. Multiple receptor conformation docking, dock pose clustering and 3D QSAR studies on human poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. J Recept Signal Transduct Res. 2014 Oct;34(5):417-30.


[Related Small Molecules]

Talazoparib | XAV-939 | MK-4827(Niraparib) | Veliparib (ABT-888) | Rucaparib (AG-014699) phosphate | PJ34 HCl | Pamiparib | Rucaparib camsylate | E-7449 | AZD2461 | G007-LK | Iniparib (BSI-201) | NMS-P118 | A-966492 | AG14361

Chemical & Physical Properties

[ Molecular Formula ]:
C17H14N2O

[ Molecular Weight ]:
262.30600

[ Exact Mass ]:
262.11100

[ PSA ]:
44.89000

[ LogP ]:
3.44960

[ Storage condition ]:
2-8℃

Related Compounds