butane-1,4-diaminium dichloride

Names

[ Name ]:
butane-1,4-diaminium dichloride

[Synonym ]:
butane-1,4-diamine dihydrochloride
1,4-Butanediamine, hydrochloride (1:2)
1,4-Diamino(butane-d8) dihydrochloride
butane-1,4-diaminium dichloride
1,4-Butane-d8-diamine dihydrochloride
1,4-Butanediamine dihydrochloride
Putrescine-d8 dihydrochloride

Biological Activity

[Description]:

1,4-Diaminobutane-d8 (dihydrochloride) is the deuterium labeled 1,4-Diaminobutane dihydrochloride[1]. 1,4-Diaminobutane (Putrescine) dihydrochloride is an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI)[2][3].

[Related Catalog]:

Research Areas >> Endocrinology

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.

[3]. E B Sequerra, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11146(2):489-93.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄H₁₄Cl₂N₂

[ Molecular Weight ]:
161.073

[ Exact Mass ]:
160.053406

[ PSA ]:
52.04000

[ LogP ]:
2.68860

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport