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WLB-89462

Names

[ CAS No. ]:
2849471-75-4

[ Name ]:
WLB-89462

Biological Activity

[Description]:

WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[Target]

Ki: 13 nM (σ2 receptor)[1]


[References]

[1]. Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66(17):12499-12519.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H29N5O3

[ Molecular Weight ]:
399.49

Related Compounds