Docosatrienoic acid

Names

[ Name ]:
Docosatrienoic acid

[Synonym ]:
13,16,19-Docosatrienoic acid, (13E,16E,19E)-
13Z,16Z,19Z-DOCOSATRIENOIC ACID
Cis,cis,cis
13C,16C,19C-DOCOSATRIENOIC ACID
CIS-13,16,19-DOCOSATRIENOIC ACID
Cis,cis,cis-13,16,19-Docosatrienoic
Docosa-13Z,16Z,19Z-trienoic acid,22:3,N-3
(13E,16E,19E)-13,16,19-Docosatrienoic acid
13-cis,16-cis,19-cis-Docosatrienoic acid
DOCOSATRIENOIC ACID
DOCOSA-13Z,16Z,19Z-TRIENOIC ACID

Biological Activity

[Description]:

Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 μM.

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

Docosatrienoic acid inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 μM[1].

[In Vivo]

Application of docosatrienic acid dose-dependently decreases the peak K+ current amplitide and accelerates the potassium activation and inactivation kinetics at all rat membrane potentials[2].

[References]

[1]. Yagaloff KA, et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids. 1995 May;52(5):293-7.

[2]. Krutetskaia ZI, et al. The effect of docosatrienoic acid on the potassium channels of outward rectification in the membrane of rat peritoneal macrophages. Fiziol Zh Im I M Sechenova. 1995 Jul;81(7):111-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
459.1±14.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₈O₂

[ Molecular Weight ]:
334.536

[ Flash Point ]:
355.8±15.2 °C

[ Exact Mass ]:
334.287170

[ PSA ]:
37.30000

[ LogP ]:
8.63

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.488

[ Storage condition ]:
2-8℃

Docosatrienoic acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds