N-Desalkylflurazepam
Names
[ CAS No. ]:
2886-65-9
[ Name ]:
N-Desalkylflurazepam
[Synonym ]:
Norfludiazepam
N-Desalkylflurazepam
Ro 5-3367
Norflutoprazepam
7-Chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-ol
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-
7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
2H-1,4-BENZODIAZEPIN-2-ONE,1,3-DIHYDRO-7-CHLORO-5-(2-FLUOROPHENYL)
EINECS 220-748-3
5-(2-Fluorophenyl)-7-chloro-1,4-benzodiazepin-2-one
Dealkylflurazepam
nor-Flurazepam
MFCD00083443
CM 7116
7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
N-DESALKYL-2-OXOQUAZEPAM
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one
Descarbethoxyloflazepate
3H-1,4-Benzodiazepin-2-ol, 7-chloro-5-(2-fluorophenyl)-
7-chloro-5-(2-fluorophenyl)-1,3-dihydrobenzo[e][1,4]diazepin-2-one
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
463.5±55.0 °C at 760 mmHg
[ Melting Point ]:
204-206°C
[ Molecular Formula ]:
C15H10ClFN2O
[ Molecular Weight ]:
288.704
[ Flash Point ]:
234.1±31.5 °C
[ Exact Mass ]:
288.046570
[ PSA ]:
41.46000
[ LogP ]:
2.40
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.648
[ Storage condition ]:
-20°C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF2370100
- CHEMICAL NAME :
- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-
- CAS REGISTRY NUMBER :
- 2886-65-9
- BEILSTEIN REFERENCE NO. :
- 0754061
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H10-Cl-F-N2-O
- MOLECULAR WEIGHT :
- 288.72
- WISWESSER LINE NOTATION :
- T67 GMV JN IHJ CG KR BF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 26RAAN "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973 Volume(issue)/page/year: -,46,1973
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
F,T
[ Risk Phrases ]:
11-23/24/25-39/23/24/25
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
DF2370100
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Xenobiotica 44(10) , 893-901, (2014)
1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydra...
Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).Forensic Sci. Int. 243 , 99-106, (2014)
The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-res...
Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samplesJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)
• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.