2-(Trimethylsilyl)ethanol

Names

[ Name ]:
2-(Trimethylsilyl)ethanol

[Synonym ]:
2-Hydroxyethyltrimethylsilane
Silane, (2-hydroxyethyl)trimethyl-
(2-Hydroxyethyl)Trimethylsilane
2-Trimethylsilylethanol
2-(Trimethylsilyl)ethanal
2-(trimethylsilyl)ethan-1-ol
MFCD00002825
trimethsilylethanol
Ethanol, 2-(trimethylsilyl)-
trimethylsilyl ethanol
2-(Trimethylsilyl)ethanol
2-TMS-ethanol
Ethanol, 2- (trimethylsilyl)-
2-Trimethylsilanyl-ethanol
EINECS 220-844-5

Chemical & Physical Properties

[ Density]:
0.825

[ Boiling Point ]:
145.0±13.0 °C at 760 mmHg

[ Melting Point ]:
0ºC

[ Molecular Formula ]:
C₅H₁₄OSi

[ Molecular Weight ]:
118.250

[ Flash Point ]:
50.6±0.0 °C

[ Exact Mass ]:
118.081390

[ PSA ]:
20.23000

[ LogP ]:
1.36

[ Vapour Pressure ]:
2.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.406

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5480000

CHEMICAL NAME :: Ethanol, 2-(trimethylsilyl)-

CAS REGISTRY NUMBER :: 2916-68-9

BEILSTEIN REFERENCE NO. :: 1732034

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H14-O-Si

MOLECULAR WEIGHT :: 118.28

WISWESSER LINE NOTATION :: Q2-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 229,1011,1976

Safety Information

[ Symbol ]:

GHS02

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S37/39-S26

[ RIDADR ]:
UN 1987 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
KM5480000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29310095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

Effects of charge, volume, and surface on binding of inhibitor and substrate moieties to acetylcholinesterase.

J. Med. Chem. 28(9) , 1309-13, (1985)

Reversible inhibitors for acetylcholinesterase, AcChE, have been studied. Sterically similar alcohols with tetra-substituted uncharged beta groups, (CH3)3SiCH2CH2OH (I), (CH3)3CCH2CH2OH (IA), and CH3S...

Generation of aza-ortho-xylylenes via ring opening of 2-(2-acylaminophenyl)aziridines: application in the construction of the communesin ring system.

Org. Lett. 8 , 3995, (2006)

A new protocol for generating aza-ortho-xylylenes via acid-catalyzed or fluoride-promoted ring opening of 2-(2-acylaminophenyl)aziridines is described. This methodology has been exploited in the rapid...

Silicon compounds as substrates and inhibitors of acetylcholinesterase.

Biochim. Biophys. Acta 791(2) , 278-80, (1984)

Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) ...