hBChE-IN-2

Names

[ CAS No. ]:
2923366-36-1

[ Name ]:
hBChE-IN-2

Biological Activity

[Description]:

hBChE-IN-2 (compound 15d) is a butyrylcholinesterase (BChE) inhibitor (IC50 of 0.62 μM) and a cannabinoid receptor 2 (CB2R) agonist. hBChE-IN-2 has neuroprotection activities[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

hBCHE:0.67 μM (IC50)

hCB2-R:0.78 μM (IC50)


[References]

[1]. Philipp Spatz, et al. Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. J Med Chem. 2023 May 11;66(9):6414-6435.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H36N4O3

[ Molecular Weight ]:
464.60

Related Compounds