PROTAC EGFR degrader 8

Names

[ CAS No. ]:
2925923-46-0

[ Name ]:
PROTAC EGFR degrader 8

Biological Activity

[Description]:

PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. PROTAC EGFR degrader 8 degrades EGFR in HCC827 cell with a DC50 of 15.56 nM. PROTAC EGFR degrader 8 inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM. PROTAC EGFR degrader 8 can be used for research of cancer, especially NSCLC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. Liang, Apeng, et al. Compounds for EGFR protein degradation and uses thereof.Patent. CN116135852.

Chemical & Physical Properties

[ Molecular Formula ]:
C40H46ClN11O5

[ Molecular Weight ]:
796.32

Related Compounds