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Luteolin-7-O-glucuronide

Names

[ CAS No. ]:
29741-10-4

[ Name ]:
Luteolin-7-O-glucuronide

[Synonym ]:
(2S,3S,4S,5R)-6-[2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
luteolin 7-O-beta-D-glucosiduronic acid
Luteolin-7-glucuronide
2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl β-D-glucopyranosiduronic acid
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranuronosyloxy)-5-hydroxy-
Luteolin 7-O-glucuronide

Biological Activity

[Description]:

Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

[Related Catalog]:

Research Areas >> Others
Natural Products >> Flavonoids

[Target]

MMP-1:17.63 μM (IC50)

MMP-3:7.99 μM (IC50)

MMP-8:11.42 μM (IC50)

MMP-9:12.85 μM (IC50)

MMP13:0.03 μM (IC50)


[References]

[1]. Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.


[Related Small Molecules]

GM 6001 | T-5224 | SB-3CT | Batimastat | Astragaloside IV | Marimastat (BB-2516) | edaravone | TAPI-2 | TAPI 1 | ISOGINKGETIN | Arctigenin | CTS-1027 | GI254023X | JNJ 0966 | CL-82198

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
892.5±65.0 °C at 760 mmHg

[ Melting Point ]:
242-244℃

[ Molecular Formula ]:
C21H18O12

[ Molecular Weight ]:
462.360

[ Flash Point ]:
315.2±27.8 °C

[ Exact Mass ]:
462.079834

[ PSA ]:
207.35000

[ LogP ]:
-0.25

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.764

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Related Compounds