DCLK1-IN-2

Names

[ CAS No. ]:
2978517-43-8

[ Name ]:
DCLK1-IN-2

Biological Activity

[Description]:

DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC50 of 171.3  nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC50 of 0.6 μM) and in vivo antitumor potency[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Cancer

[References]

[1]. Yuepeng Chen, et al. Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer. European Journal of Medicinal Chemistry. 7 October 2023, 115846.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H32N8O3S

[ Molecular Weight ]:
536.65

Related Compounds