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Meconin-d3

Names

[ CAS No. ]:
29809-15-2

[ Name ]:
Meconin-d3

[Synonym ]:
Meconin-d3
1(3H)-Isobenzofuranone, 6-methoxy-7-(methyl-d-oxy)-
Meconic Lactone-d3
Opianyl-d3
6-Methoxy-7-[(H)methyloxy]-2-benzofuran-1(3H)-one
6,7-Dimethoxyphthalide-d3

Biological Activity

[Description]:

Meconin-d3 is the deuterium labeled Meconine. Meconine is an endogenous metabolite[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Jones JT, et al. Detection of codeine, morphine, 6-monoacetylmorphine, and meconin in human umbilical cord tissue: method validation and evidence of in utero heroin exposure. Ther Drug Monit. 2015;37(1):45-52.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
404.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H7D3O4

[ Molecular Weight ]:
197.202

[ Flash Point ]:
185.1±28.8 °C

[ Exact Mass ]:
197.076736

[ PSA ]:
44.76000

[ LogP ]:
0.63

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.548

Related Compounds